pS313-MRGPRX2 (phospho-MRGPRX2 Mas-related Receptor Antibody)

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Agonist-induced Serine313 phosphorylation of the MRGPRX2 Mas-related Receptor

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Order number: 7TM0157A
Content: 100 µl
Host: Rabbit

Serine313 (S313) is a major phosphorylation site of the MRGPRX2 Mas-related receptor.... more

Serine313 (S313) is a major phosphorylation site of the MRGPRX2 Mas-related receptor. The pS313-MRGPRX2 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S313 phosphorylation is a key regulator of MRGPRX2 desensitization, β-arrestin recruitment and internalization.

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Alternative Names MRGPRB 10, MRGX2 IUPHAR Target ID 157... more

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Alternative Names	MRGPRB 10, MRGX2
IUPHAR Target ID	157
UniProt ID	Q96LB1
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human MRGPRX2 around the phosphorylation site of Ser313.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine313 phosphorylation of the MRGPRX2 Mas-related Receptor.... more

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Figure 1. Agonist-induced Serine313 phosphorylation of the MRGPRX2 Mas-related Receptor. Upper panel, HEK293 cells stably expressing the MRGPRX2 Receptor (MRGPRX2) were either not exposed or exposed to 100 nM specific agonist ZINC-3573 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS313-MRGPRX2 antibody (7TM0157A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-MRGPRX2 antibody to confirm equal loading of the gel.

Be the first to decipher the MRGPRX2 phosphorylation barcode and let us know. more

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Be the first to decipher the MRGPRX2 phosphorylation barcode and let us know.

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